Calendula flower is used to prevent muscle spasms, start menstrual periods, and reduce fever. It is also used for treating sore throat and mouth, menstrual cramps, cancer, and stomach and duodenal ulcers. Calendula has also been used for measles, smallpox, and jaundice.

Calendula is applied to the skin to reduce pain and swelling (inflammation) and to treat poorly healing wounds and leg ulcers. It is also applied to the skin (used topically) for nosebleeds, varicose veins, hemorrhoids, inflammation of the rectum (proctitis), ear infection, gum disease, peeling lips (exfoliative cheilitis), diaper rash, vaginal yeast infection, and inflammation of the lining of the eyelid (conjunctivitis).